Hydrocortisone A corticosteroid commonly prescribed for the treatment of mild to severe acne, eczema or dry skin, hydrocortisone rapidly calms skin to reduce the intensity of pain, itching and swelling. Formulated to treat skin with therapeutic benefits, this 2.5% hydrocortisone face cream can help relieve skin irritations, rashes and flare ups. Best used as a hydrocortisone cream for acne, dryness or itchy skin, it soothes, smooths and reduces puffiness to support toning, firming and radiance.